In recent years, stainless steel has seen increased use in construction due to its exceptional corrosion resistance and mechanical strength, especially in structural elements like channel sections, hollow pipes, and angles. Cold-formed stainless steel (CFSS) channel sections with edge-stiffened web holes have emerged as a significant development in the construction industry, with a focus on streamlining the installation of plumbing and electrical services. Previous research indicated that these edge stiffened web holes offer comparable axial capacity to plain webs in cold-formed steel (CFS) channel columns. In building industry, stiffening of the web hole is very common, which results in increase of the load carrying capacity of the stainless-steel column. However, no comprehensive study has been reported in the literature for such stainless-steel column subjected to compression. This paper investigates the axial capacity of the stainless-steel column with unstiffened and edge-stiffened web holes. A non-linear finite element (FE) model is developed and validated against the experimental results available in the literature. An extensive parametric study is conducted based on 2016 validated FE models. EN 1.4509 (Ferritic), EN 1.4462 (Duplex) and EN 1.4301 (Austenitic) grades of stainless steel are considered for the current study. Subsequently, parametric study results are compared with guidelines available for stainless steel in the standards, namely AS/NZS 4600: 2018, ASCE: 08, AISI. Finally, a modified EWM and DSM equations are proposed for the CFSS section with edge-stiffened web holes. Finally, a reliability analysis was conducted to ensure that the proposed equation could be reliable.