In New Zealand, edge-stiffened holes have been recently introduced to cold-formed steel channels (CFS) to facilitate the installation of plumbing and electrical systems. Previous studies on cold-formed carbon steel (CFCS) channels have demonstrated that using edge-stiffened web holes provides nearly the same strength as an equivalent channel section with a plain web when facing web crippling. However, there is a lack of experimental or numerical investigations into the application of edge-stiffened web holes in cold-formed stainless steel (CFSS) channels in the existing literature. This thesis builds upon previous studies conducted on CFCS channel sections. It presents a comprehensive numerical examination of the web crippling behavior of CFSS channel sections with edge-stiffened circular web holes under interior-two-flange (ITF) and end-two-flange (ETF) loading conditions. Three stainless steel grades were considered: EN 1.4509 (Ferritic), EN 1.4462 (Duplex), and EN 1.4301 (Austenitic). A parametric study involving 3,744 non-linear finite element (FE) models was developed for both fastened and un-fastened flange cases. The study covered the impact of different hole sizes, edge-stiffener lengths, channel inner radius, and the length of the bearing plates. The results of the parametric study were used to establish new equations for web crippling strength and strength reduction factors through non-linear regression analysis. These proposed design equations outperformed predictions from American Society of Civil Engineers Specification (ASCE 8-02), American Iron and Steel Institute Specification, Australian/New Zealand Standard (AISI&AS/NZS), and Eurocode 3. Finally, a reliability analysis was conducted, revealing that the proposed design equations accurately predict the web crippling strength of CFSS channel sections with plain webs, unstiffened web holes, and edge-stiffened web holes under two-flange loading conditions.